Glyceraldehyde 3-phosphate dehydrogenase, EC 1.2.1.12

published: 21 Nov 2011 (14:59)

About Glyceraldehyde 3-phosphate dehydrogenase

Glyceraldehyde 3-phosphate dehydrogenase is an enzyme from Oxidoreductase family (EC 1.2.1.12), with molecular weight around 75kDa, that phosphorylate D-glyceraldehyde-3-phosphate. The overall reaction can be written as D-glyceroaldehyde-3-phosphate + NAD⁺ +P_i <=> 1,3-Bisphosphoglycerate + NADH + H⁺

Systematic name for Glyceraldehyde 3-phosphate dehydrogenase is D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating) , but in literature can be used many other names: 3-phosphoglyceraldehyde dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase (NAD); phosphoglyceraldehyde dehydrogenase; glyceraldehyde phosphate dehydrogenase (NAD); NADH-glyceraldehyde phosphate dehydrogenase; NAD-dependent glyceraldehyde phosphate dehydrogenase; glyceraldehyde-3-P-dehydrogenase and triosephosphate dehydrogenase.

Glyceraldehyde 3-phosphate dehydrogenase IUBMB Enzyme Nomenclature hierarchy

Glyceraldehyde 3-phosphate dehydrogenase classification on the basis of recommendations of Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB):

EC 1 Oxidoreductases
- EC 1.2 Dehydrogenases that act on aldehyde or oxo- group of donors
  - EC 1.2.1 with NAD⁺ or NADP⁺ as acceptors
    - EC 1.2.1.12 D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)

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