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1. Hexokinase
2. Phosphoglucoisomerase
3. Phosphofructokinase
4. Aldolase
5. Triose phosphate isomerase
6. Glyceraldehyde-3-phosphate dehydrogenase
7. Phosphoglycerate kinase
8. Phosphoglycerate mutase
9. Enolase
10. Pyruvate kinase

Phosphofructokinase, EC

published: 21 Nov 2011 (14:32)

About Phosphofructokinase

Phosphofructokinase are group of enzymes of transferases family (EC, with molecular weight about 30-50kDa per monomer which contains 300-500 amino acid residues. Usually phosphofructokinase biological unit is tetramer.

Phosphofructokinase catalyse phosphorilation of C1-hydroxyl group of D-Fructose-6-phosphate with phosphate group from ATP with formation of D-Fructose-1,6-bisphosphate and ADP. The overall reaction can be written as ATP + D-Fructose-6-phosphate -> ADP + D-Fructose-1,6-bisphosphate. This reaction is exothermic (δGo = -18.5 kJ/mol or -4,41 kcal/mol). Phosphofructokinase can also use sedoheptulose 7-phosphate and D-Tagatose 6-phosphate as acceptors and Uridine triphosphate (UTP), Cytidine triphosphate (CTP) and Inosine triphosphate (ITP) as donors. Optimum pH for Phosphofructokinase is between 7.3 and 8.0.

Systematic name for 6-phosphofructokinase is ATP:D-fructose-6-phosphate 1-phosphotransferase, but in literature can be used under the different names: PFK, phosphofructokinase I, nucleotide triphosphate-dependent phosphofructokinase, D-fructose-6-phosphate 1-phosphotransferase, fructose 6-phosphate kinase, phosphofructokinase (phosphorylating), 6-phosphofructose 1-kinase, phospho-1,6-fructokinase, phosphohexokinase, fructose 6-phosphokinase and ATP-dependent phosphofructokinase.

Phosphofructokinase IUBMB Enzyme Nomenclature hierarchy

Phosphofructokinase classification on the basis of recommendations of Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB):
  • EC 2 Transferases
    • EC 2.7 Transferases that transfer phosphorus containing groups
      • EC 2.7.1 With alcohol group action as acceptor
        • EC ATP:D-fructose-6-phosphate 1-phosphotransferase


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