Phosphoglucoisomerase, EC 5.3.1.9

published: 21 Nov 2011 (14:11)

About Phosphoglucoisomerase

Phosphoglucoisomerase are group of enzymes of isomerases family (EC 5.3.1.9), with very wide range of molecular weight, from 40 to 120kDa, that catalyze transfer of phosphate group from ATP molecule to D-glucose or other D-hexoses. The overall reaction can be written as ATP + D-hexose = ADP + D-hexose 6-phosphate. This enzyme is very important because it involved into glycolysis cycle at the first step of converting of α-D-glucose.

Systematic name for phosphoglucoisomerase is D-glucose-6-phosphate aldose-ketose-isomerase , but in literature can be used under the different names: hexose phosphate isomerase, phosphoglucoisomerase, phosphohexomutase, D-glucose-6-phosphate ketol-isomerase, phosphohexose isomerase, glucose phosphate isomerase, phosphosaccharomutase, phosphohexoisomerase, oxoisomerase, hexosephosphate isomerase and phosphoglucose isomerase.

Phosphoglucoisomerase IUBMB Enzyme Nomenclature hierarchy

Phosphoglucoisomerases classification on the basis of recommendations of Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB):

EC 5 Isomerases
- EC 5.3 Isomerases that acts as an Intromolecular Oxidoreductases
  - EC 5.3.1 Acting on Aldoses and Ketoses
    - EC 5.3.1.9 D-glucose-6-phosphate aldose-ketose-isomerase

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