5. Triose phosphate isomerase
6. Glyceraldehyde-3-phosphate dehydrogenase
7. Phosphoglycerate kinase
8. Phosphoglycerate mutase
10. Pyruvate kinase
Hexokinase, EC 18.104.22.168
published: 21 Nov 2011 (15:08)
About HexokinasesHexokinases are group of enzymes of transferase family (EC 22.214.171.124), with very wide range of molecular weight, from 40 to 120kDa, that catalyze transfer of phosphate group from ATP molecule to D-glucose or other D-hexoses. The overall reaction can be written as ATP + D-hexose = ADP + D-hexose 6-phosphate. This enzyme is very important because it involved into glycolysis cycle at the first step of converting of α-D-glucose.
Systematic name for hexokinase is ATP:D-hexose 6-phosphotransferase, but in literature can be used under the different names: hexokinase D, hexokinase (phosphorylating), hexokinase type IV glucokinase, ATP-dependent hexokinase, glucose ATP phosphotransferase, hexokinase type I, hexokinase type II, hexokinase type III and hexokinase type IV.
Open and Closed glucokinase conformations
In closed conformation of hexokinase, or glucokinase, the substrate is completely buried by protein atoms.
Hexokinase IUBMB Enzyme Nomenclature hierarchyHexokinase classification on the basis of recommendations of Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB):
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