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Glycolysis
Enzymes:
1. Hexokinase
2. Phosphoglucoisomerase
3. Phosphofructokinase
4. Aldolase
5. Triose phosphate isomerase
6. Glyceraldehyde-3-phosphate dehydrogenase
7. Phosphoglycerate kinase
8. Phosphoglycerate mutase
9. Enolase
10. Pyruvate kinase
Compounds:
ATP
ADP
Glucose
Pyruvate

Pyruvate kinase, EC 2.7.1.40

published: 21 Nov 2011 (16:19)

About Pyruvate kinase

Pyruvate kinase is an enzyme from Transferase family (EC 2.7.1.40), with molecular weight within 50-60kDa range for monomer (biological unit usually tetramer), transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP. The overall reaction can be written as Phosphoenolpyruvate + H+ + ADP -> Pyruvate + ATP

Systematic name for Pyruvate kinase is ATP:pyruvate 2-O-phosphotransferase, but in literature other names are also acceptable: pyruvic kinase; phosphoenol transphosphorylase; phosphoenolpyruvate kinase; pyruvate phosphotransferase; pyruvate kinase (phosphorylating); fluorokinase (phosphorylating); and fluorokinase.

Pyruvate kinase IUBMB Enzyme Nomenclature hierarchy

Pyruvate kinase classification on the basis of recommendations of Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB):
  • EC 2 Transferases
    • EC 2.7 Transferases that transfer groups with phosphorus atoms
      • EC 2.7.1 Phosphotransferases with an alcohol group as acceptor
        • EC 2.7.1.40 ATP:pyruvate 2-O-phosphotransferase

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